EPIGENETICS (FUNDAMENTALS)
QUOTE: Epigenetics is the study of heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence — a change in phenotype without a change in genotype — which in turn affects how cells read the genes. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state. Epigenetic modifications can manifest as commonly as the manner in which cells terminally differentiate to end up as skin cells, liver cells, brain cells, etc. Or, epigenetic change can have more damaging effects that can result in diseases like cancer.
DNA IS NOT DESTINY
EXTRACT:
DNA Is Not Destiny: The New Science of Epigenetics
Discoveries in epigenetics are rewriting the rules of disease, heredity, and identity.
By Ethan Watters|Wednesday, November 22, 2006
Back in 2000, Randy Jirtle, a professor of radiation oncology at Duke University, and his postdoctoral student Robert Waterland designed a groundbreaking genetic experiment that was simplicity itself. They started with pairs of fat yellow mice known to scientists as agouti mice, so called because they carry a particular gene—the agouti gene—that in addition to making the rodents ravenous and yellow renders them prone to cancer and diabetes. Jirtle and Waterland set about to see if they could change the unfortunate genetic legacy of these little creatures.
PLEASE DRAW YOUR OWN CONCLUSIONS ABOUT THE POSSIBLE EFFECTS OF NEUROTOXINS ON GENE EXPRESSION!
PLEASE DRAW YOUR OWN CONCLUSIONS ABOUT THE POSSIBLE EFFECTS OF NEUROTOXINS ON GENE EXPRESSION!
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