AN INVESTIGATION REPORTED IN AUSTRALIAN AND NEW ENGLAND JOURNAL OF PSYCHIATRY
Results: Overall, new generation (atypical) antipsychotics (90%, 9/10 agents) and anticonvulsants (85.7%, 6/7 agents) showed the highest evidence of carcinogenicity among psychotropic drugs classes assessed. Antidepressants (63.6%, 7/11) and benzodiazepines/sedative-hypnotics (70%, 7/10) were next, and stimulants (with the exception of methylphenidate) were last (25%, 1/4 agents). Overall, 71.4% of all drugs examined (30/42) showed evidence of carcinogenicity in 43.2% (38/88) of specific experimental studies.
Conclusions: US Food and Drug Administration–based analyses demonstrate that almost all atypical antipsychotics and anticonvulsants are carcinogenic in animals, as are the majority of antidepressants and benzodiazepines and methylphenidate. These animal-based results are not sufficient to draw definitive conclusions in humans, but they provide data that could be acknowledged in the informed consent process of clinical treatment.
A carcinogen is any substance, radionuclide, or radiation that is an agent directly involved in causing cancer. This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes.
CARCINOGEN (Wiki)
Matt Ball Wow. Thank you for sharing. Just read the complete article. thought this summed it up well and very worryingly! “although this association cannot establish that all agents
and mixtures that cause cancer in experimental animals
also cause cancer in humans, nevertheless, in the absence
of adequate data on humans, it is biologically plausible and
prudent to regard agents and mixtures for which there is
sufficient evidence of carcinogenicity in experimental animals
as if they presented a carcinogenic risk to humans”.
(International Agency for Research on Cancer (IARC) and
World Health Organization, 2000). I do wonder when we will stop dealing these drugs and acknowledge the myriad issues with them
Matt Ball Wow. Thank you for sharing. Just read the complete article. thought this summed it up well and very worryingly! “although this association cannot establish that all agents
and mixtures that cause cancer in experimental animals
also cause cancer in humans, nevertheless, in the absence
of adequate data on humans, it is biologically plausible and
prudent to regard agents and mixtures for which there is
sufficient evidence of carcinogenicity in experimental animals
as if they presented a carcinogenic risk to humans”.
(International Agency for Research on Cancer (IARC) and
World Health Organization, 2000). I do wonder when we will stop dealing these drugs and acknowledge the myriad issues with them
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